Adverse Effects is a video game that puts gamers in the shoes of a person faced with a difficult moral dilemma. Judith, a character in the title, suffers from insomnia, which forces her to seek medical help. The doctor prescribes her an experimental sleeping pill, but instead of simply helping her sleep, it causes unintended consequences. While taking the medicine, the lady experiences unexpected emotions that intensify her feelings for the user's hero. The person works two jobs, her fatigue is palpable, which forces her to seek relief in medications. However, the pills she is prescribed turn out to have a twist, changing her behavior and emotions in unexpected ways.

Despite her initial confusion, the woman begins to be drawn to the user's character, and her affection develops into something deeper and more intense. As the title progresses, gamers are faced with difficult decisions while navigating the complexities of a woman's altered state. Should they reciprocate her new feelings, knowing that they are caused by the adverse effects of the drug? Or should they resist, reflecting on the ethical implications of indulging in relationships built on altered perceptions? Adverse Effects addresses themes of morality, consent, and the consequences of medical intervention.