AGAINST is a game for virtual reality glasses that focuses on the rhythm and atmosphere of comics. Following the music and rhythm, the player will have to fight the minions of the mad Doctor Weiss. Angry opponents are gradually becoming stronger and only hitting the right beat will help you defeat them and advance to the next levels. The main character finds himself in mortal danger among the gloomy streets of the city, where opponents roam everywhere.

The gameplay takes the user to the streets of the city, where they will participate in musical chases while escaping from criminals. The controlled character runs along walls, dodges obstacles and neutralizes opponents to the dynamic soundtrack. As the player progresses through the levels, he uncovers the secrets of the evil Doctor Weiss and what he wants to achieve with his horrific actions.

The protagonist uses a slashing sword and cuts enemies into pieces, and also shoots them with a pistol. To achieve a high rating, the user will need to be on time and perform actions perfectly. The arsenal also includes Tommy Gun and brass knuckles, which can be changed during the process. The plot reveals the doctor's true desires through a sketched comic book set in America in the mid-20th century. The campaign consists of 7 chapters and has three difficulty levels to choose from.