According to the plot Bus Simulator 18 The action takes place in a city where the authorities have abandoned their bus system, so the player bus driver and his colleagues take on the task of bringing back the popularity of this form of passenger transport and demonstrating to local officials that buses are vital. This means managing not only a clean, efficient and on-time bus, but also a growing business as new vehicles, employees, etc. are added.

In the Bus Simulator 18 game, players can customize almost everything in the company – routes, employees, appearance of cars, uniforms and much more. As the gameplay progresses, the gamer will be given more and more customization options. In addition, here you can let AI control most of your daily life. The peculiarity of the game is that the routes to be overcome can be as long or short as the gamer wants. There's also the ability to send your drivers on routes, monitor their progress, and even collaborate with them to make it feel like a true team effort.

During the ride, gamers will have to stop and pick up passengers by opening multiple doors, lowering wheelchair devices, obeying traffic rules, and even returning the correct change for purchased tickets. This is a game about owning and managing a bus fleet in fictional cities, and is highly realistic.