The main character Kana: Little Sister a young man named Takamichi Todo is acting. He lives an ordinary life, despite the fact that he has problems in his family. The fact is that he has a younger sister, Kana. The girl has tender feelings for her brother, and it seems that they are more serious than family ties. At the same time, the young lady is suffering from a serious illness. Most of the time she is in the hospital, and doctors are unable to help. In this case, the user watches the development of the relationship. It raises philosophical questions about life and death, family values, human support. One of the tasks is to help the girl overcome a difficult situation. Other characters are involved here. This is Taki Yumi Kashima, the young man's ex-girlfriend. Yuta Ito, his sister's classmate, head over heels in love with her. Miki Kondo, a nurse from the hospital.

The game Kana: Little Sister is made in the form of a novella, drawn in anime style. The player personally takes part in the action. This is due to participation in dialogues. In this case, it is necessary to choose one of the provided lines. Actions affect the development of the storyline. This leads to one of the available endings. There are six different endings. They can be both positive and negative. Conversations are diluted with illustrated scenes. Some of them are erotic. Recommended for users who have reached the age of majority.