The protagonist of Lust Epidemic is a young student named Brad, who is forced to leave his city and university due to a severe natural disaster. A serious hurricane hits the settlement, causing severe damage. As a result, many people move, like the hero. He finds himself in another educational institution, where most of the students and teachers are very beautiful representatives of the fair sex, who are very happy with male attention, because they have lacked it so much all these years.

Lust Epidemic is unlike many visual novels in that it allows you to freely explore the virtual world with an isometric view from above. You can talk to each character. Most of the time will have to be devoted to dialogues, through which the storyline is presented. The hero's goal is quite classic for the genre – to have as many romantic relationships as possible. To do this, it is very important to carry out small tasks for beauties and answer questions correctly in dialogues.

If the user practically does not make mistakes in communication, then the attitude towards him quickly changes for the better and many women are ready to get closer to him up to a bed scene. They are drawn as in classic novels. The game is designed exclusively for an adult audience, as it shows numerous frames of a pornographic nature.