Detective story Magical Eyes – Red is for Anguish is filled with an atmosphere of impending danger from unknown dark forces. Here we will be told about a strange incident that took place on the street of one of the Japanese cities. On a dark April night, a local police operator received a message that someone had cut off the left hand of the owner of a small store. The victim himself survived, but apparently being in a state of shock, he says that the injuries were inflicted on him by a strange doll that had been on one of the counters for a long time. However, after the incident, the doll along with the severed hand mysteriously disappeared. It is difficult to believe the words of the victim, but he himself is sure that everything happened exactly like that.

The main character of the visual detective Magical Eyes – Red is for Anguish has to find out all the details of what happened. To do this, he needs to explore the area where the crime occurred in search of clues and evidence, as well as talk to those people who may know some important details. Players will be able to get acquainted with the plot by reading the text on the screen, which will describe what is happening or display the characters' dialogues. The dialogue box is displayed against the background of pictures with locations and characters. The player can influence the development of the plot with his actions, directing the investigator to places of interest and choosing answers in conversations.