Quest Nancy Drew: Legend of the Crystal Skull begins with Nancy Drew and her friend Bess Marvin arriving in New Orleans for a break from constant investigations. However, before having fun, she stops by to see Henry, a friend of her friend Ned. Recently, a close relative of a guy died. At first glance, the task is very simple, because you just need to visit the old house, talk to Henry, express your regrets and leave. However, upon entering the estate, she is stunned by a skeleton. Having come to her senses, she needs to conduct another investigation and understand why exactly the skeletal man attacked her, and what he is doing in the old house.

The characters featured in The Legend of the Crystal Skull are:

• Henry is the grandson of the deceased Bruno, who was tasked with taking care of his great-uncle's inheritance.
• Renee is a friend of the deceased who practices Voodoo magic.
• Gilbert is the attending doctor and a good friend of the deceased.
• Lamont is a consultant at a local store.
• Milo is one of the scientists in the laboratory.
• Marvin is a close friend who helps her in her case.
• Ned is Drew's boyfriend, helping her on the phone and others.

Teaming up with her friend, the heroine will have to unravel the secrets of the mysterious house and the mystical artifact that Bruno possessed. During the investigation, the main character will have to meet a spider, an alligator, an iguana and other opponents. By entering secret rooms, you can unlock crypts by collecting glass eyeballs. You can play on easy and hard levels and remove errors without going through the game again.