Nope Nope Nope Nurses takes him on a journey through a chaotic hospital environment, where an encounter with the infamous “OG Three” becomes an inevitable challenge for Yamada. These experienced nurses don't hold back and use every dirty trick possible to keep their patients on their toes. As the protagonist navigates a dangerous landscape, the tension builds, making her nervous.

A distinctive feature is the full Japanese voice acting, performed by experienced professionals. This element brings the characters to life, adding depth and emotion to their interactions. The OG Three's relentless whispers and ominous taunts create an atmosphere of unease, reinforcing the connection to the plight. Among the infamous trio, Numajiri stands out as the most formidable.

Her relentless quest to upset the heroine is relentless, weaving a web of psychological torment. Regardless of the situation, Numajiri’s presence is a constant shadow, an obsessive reminder of the problems that the girl faces within the walls of the hospital. Kiritani, another member of the trio, brings an unexpected twist to the story. Despite rumors about her turbulent past, he surprises with his kind behavior and outward elegance. The stark contrast between her appearance and reputation challenges preconceived notions, adding depth to her character.