Nope Nope Nurses is a visual novel style game that starts with the main character getting stuck in a hospital bed. The nurses take care of him and his needs. However, the guy faces certain problems related to their needs. He will have to experience an unusual life with demons in white robes, communicate with them and try not to go crazy. The protagonist finds himself in a hospital where the worst nurses are collected.

The player will have to take control of a young guy named Yamada, who suffers from a rare disease. One day he breaks the bones in both his arms, after which he finds himself in a medical bed with attractive nurses attending to his every need. Gradually he encounters and discovers the demonic nature of the local employees. The guy will need to try not to lose his sanity and leave the hospital healthy.

The plot progresses in a classic visual novel style. The gamer will participate in numerous dialogues with minor characters. Inside the hospital, the main character will meet different girls. Each of them has a unique character that influences how they will react to certain user actions. During the passage, the user will more than once need to make choices that affect the further narrative and what events will happen.