Events Nostradamus: The Last Prophecy take place in France, during the heyday and establishment of the monarchy. Trouble comes to the royal family. The august persons begin to die one after another. An unknown disease is to blame for everything. Sensing a catastrophe, Marie de Medici turns to the famous fortune teller and alchemist Nostradamus. He has no right to refuse this important matter. But he understands that due to his age and decrepitude, he will not be able to cope with the task. Then he asks his own daughter Madeline for help. The girl goes to the Salon-de-Provence region, where the royal residence is located. She has to pretend to be Caesar's older brother. This is a necessary measure. After all, the local population will be suspicious and prejudiced when visiting a young lady who is engaged in astronomy and alchemy.

The user in Nostradamus: The Last Prophecy controls the actions of the main character. In this case, it is necessary to conduct a full investigation and identify the circumstances and reasons for what is happening. To achieve this goal, you should interact with the surrounding objects, talk and find out information from secondary participants. At the same time, in some dialogues there is an opportunity to choose lines or phrases. Also, to find evidence and clues, you will have to prepare protective or healing potions from different components. To solve the puzzle, you need to visit many locations. But there is no freedom of movement and action. The levels are completed in turn, and the character is transferred to the next stage after the completion of the previous round.