OMSI 2: Bus Simulator offers you to play the role of an omnibus driver, moving through vast streets and other areas, exploring the environment and earning in-game funds. The second part includes many innovations that improved the gameplay and graphics. The location is open for exploration and has become larger than in the first edition.

The player will have to discover different places in Spandau by controlling the omnibus. Standard routes and buses from the first part are presented. New functions and capabilities for the user have also been added. The gamer can control the vehicle with an articulated frame called MAN-NG272. A new line has appeared for travel with a distance of 12 kilometers from the Rukhleben metro station. An event that takes the user back in time will help you see the actions that took place from 1986 to 1994.

The story campaign covers the years after German reunification, as well as expanded and added routes following changes in the country. The user has the opportunity to change the map or road by calling construction sites or using special buses. The damage system is believable. In the event of a collision, various parts of the vehicle will stop working, affecting speed or handling. The gamer can take advantage of new aspects such as automatic import of aerial photographs, adapt the landscape to travel on the road, or use the modernized spline connection function.