School of Lust talks about a young guy who entered an elite school. He was accepted into an educational institution where only girls study. He and his parents don't understand why they decided to send him to a women's college, but they couldn't do anything about it. However, the main character is not discouraged by this decision, because he finds himself surrounded by attractive girls, many of whom catch their eye and will flirt with him, the only guy.

For several months the boy enjoyed communicating with beautiful girls and made plans on how to seduce each of them. One day in the corridor he accidentally came across the body of his friend, and a few days later the situation happened to another woman, and a week later another murdered woman was discovered. The atmosphere of the educational institution suddenly changed to a more silent and gloomy one, because no one knew what happened, and everyone mourned the dead.

The central character is distracted from his routine activities of seducing girls and decides to conduct his own investigation, finding the criminal or the source of the death of innocents. In the gameplay, the user will have to solve puzzles, explore the environment and find tricks that will allow them to discover the truth of what happened. As you progress, there are erotic scenes with various minor characters. The gamer's choices influence the further development of the narrative and who sexual activities will be unlocked with.