According to the plot Strike Suit Zero The future of the Earth hangs in the balance. After decades of expansion and colonization across the universe, disparate human factions are fighting for independence. Players take on the role of faceless soldier Adam, who must defend the United Nations of Earth from a colonial attack. Before purchasing the main combat vehicle, gamers will need to go through some introductory instructions on a standard fighter to get used to the controls. Airplanes are extremely fast, and the test vehicle is no exception. They also have the ability to disable incoming missiles by releasing an electromagnetic pulse.

Each of the 4 ships used throughout the Strike Suit Zero campaign is capable of simultaneously equipping different types of guns and missiles. Most scenarios are flexible enough that you can design your own gear without compromising your chances of success, since that responsibility ultimately falls on the ability to strike or retreat at key moments. Here it makes more sense to use standard machine guns or plasma shells, rather than automatically targeting each enemy from the very beginning, so as not to run out of ammo early. If this happens, it will mean failure, since there are no objects or resources to collect in the vastness of space.

The campaign takes approximately 10 hours to complete, but there are plenty of incentives to replay each mission, including powerful ship upgrades and alternate endings. Each mission has secondary objectives that can be completed to unlock new armor or weapons, and these objectives usually involve defending or destroying a specific ship during battle.