History in Yakuza Revenge begins with how the head of the Yakuza dies, and his entourage hides this incident. If others find out that such a powerful and influential person has died, then a struggle for power and territory will begin. Because of this, a powerful clan decides to create a clone of the deceased boss. The first mission in the walkthrough begins at a secret plant located on the coast of America.

In the first level of Revenge of the Yakuza, the player will need to escape from a heavily guarded secret location after stealing biomaterial. In total, the gameplay features 4 playable characters with their own characteristics, additional mechanics and missions. Sometimes they will act alone or in a team. The first of the heroes involved in the intrigue takes the user into a mission where he will participate in chases, ambushes and car accidents.

The characters' paths gradually converge as they progress. The gamer will have to control a policeman, a rebel, a journalist and a young Yakuza boss. The passage shows the cruelty of a clan created against the backdrop of modern realities. Dynamic artificial intelligence that controls enemies, uses elements of the environment and helps allies, creating more difficulties for the user. At some levels you will need to participate in car shootouts or battles with automatic weapons.