Yu-Gi-Oh! The Duelists of the Roses, a unique fusion of a card game and the historical backdrop of the Wars of the Roses, features intriguing gameplay. In this virtual setting, users find themselves drawn into a conflict reminiscent of the real-life struggle between the Lancastrian and York factions. The story unfolds from the point of view of the two main characters, Yugi and Kaiba, mirroring the roles of historical figures Henry Tudor and Christian Rosenkreutz. As duelist Rose, summoned by a mystical druid, gamers are tasked with helping one side in this fictional war. Yu-Gi-Oh! The Duelists of the Roses takes place in two different storylines, each corresponding to the player's chosen allegiance.

The main goal is clear: collect all 16 Rose cards, which are held by the main opponents of each faction. These cards have the uncanny ability to summon the fearsome Manawyddan fab Llyr, a legendary dragon that can tip the scales and end a conflict. Throughout the entire title, users encounter a variety of characters from the series. Each opponent presents a unique challenge, wielding different decks and strategies that reflect both their personalities and their historical counterparts. These dynamics add additional complexity to gameplay, and strategic thinking and adaptability are paramount to success on the virtual battlefield.